Indications
For the active immunisation of sheep against pulpy kidney, malignant oedema, blackquarter, tetanus and pasteurellosis caused by the above listed organisms. In particular the vaccine is recommended as an aid in the prevention of pneumonic and septicaemic pasteurellosis in lambs.

Composition:
An opaque fluid vaccine prepared from the purified formol toxoids of Clostridium perfringens (Cl. welchii) type D, Clostridium septicum, Clostridium tetani, purified formalin killed cultures of Clostridium chauvoei and antigens from the epidemiologically most important A and T serotypes of Mannheimia (Pasteurella) haemolytica in buffered physiological saline and absorbed onto aluminium hydroxide. The product is preserved with 0,013 % thiomersal.

Warnings:

• Keep away from children, uninformed persons and animals.
• Partly used packs should be destroyed at the end of a day’s operations as puncture of the rubber cap could cause contamination of the remaining contents.
• As with all vaccines, occasional hypersensitivity reactions may occur.
• Although this remedy has been extensively tested under a large variety of conditions, failure thereof may ensue as a result of a wide range of reasons. If this is suspected, seek veterinary advice and notify the registration holder.

Directions for Use: Use only as directed.

• SHAKE WELL BEFORE USE.
• Administration is by subcutaneous injection in the loose skin on the side of the upper neck, observing aseptic precautions.
• Syringes and needles should be from gamma irradiated packs or freshly sterilised by boiling for at least 20 minutes.
• No alcohol or other disinfectants should be used for sterilisation.
• The bottle containing this product is collapsible and it is not necessary to inject air into the bottle to enable vaccine to be withdrawn.
• It is, therefore, suitable for use with an automatic reloading injection syringe without using an air tube through the bottle cap.
• The instructions supplied with such syringes should be noted and care should be taken to ensure the delivery of the full dose, particularly with the final few doses from the bottle.
• The vaccine contains an adjuvant which may cause a temporary nodule at the site of injection.
• In any group of animals, a small number of individuals may fail to respond to vaccination as a result of immunological incompetence or for some other reason.
• Satisfactory immune responses will only be attained in healthy animals, thus it is important to avoid vaccination of animals which have intercurrent disease or which have a poor nutritional status.
• As with most killed vaccines, significant levels of immunity cannot be expected until two weeks after the second dose of the primary vaccination course.
• When vaccinating animals, stress should be avoided, particularly during later stages of pregnancy when there is a risk of inducing abortion or metabolic disorders.

Dosage:

• Sheep of all ages 2 ml subcutaneously with the dosage repeated after an interval of four to six weeks.
• Lambs born to vaccinated ewes could be expected to have colostral protection for up to four weeks against Mannheimia (Pasteurella) haemolytica and for up to 12 weeks against the clostridial diseases listed above.
• Lambs being retained will thus require a full vaccination programme themselves.
• The timing of the first injection should be carefully considered so that the full vaccination programme can be completed before the period of expected risk of diseases due to Mannheimia (Pasteurella) haemolytica or clostridia.
• Pasteurellosis due to infection with Mannheimia (Pasteurella) haemolytica A serotypes usually occurs in late spring or early summer, whereas septicaemic pasteurellosis associated with infection due to Mannheimia (Pasteurella) haemolytica T serotypes usually occurs in late summer or autumn.
• Lambs born to unvaccinated ewes should be given a first injection of 2 ml vaccine during the first week of life and a second injection of 2 ml four to six weeks later.
• In areas of high incidence of pulpy kidney disease it may be advisable to give a third dose of vaccine to lambs born early in the year during the first year of life.

Storage Instructions:

• Store in a cool place (2 ºC - 8 ºC). If stored in a refrigerator at ± 2 ºC - 8 ºC, it may be expected to retain its potency up to the expiry date printed on the package.
• Do not freeze.
• Protect from light.

Presentation:
100 ml (50 dose), 250 ml (125 dose) and 500 ml (200 dose) collapsible low density polyethylene containers.

Registration Holder:
Intervet S.A. (Pty) Ltd
Co. Reg. No. 1991/006580/07