Composition:
Each impregnated sponge contains 40 mg Fluorogestone acetate.

Pharmacological Classification:
C20.4 Ovulation controlling agents and prostoglandins.

Pharmacological Action:
Whilst in the vagina the sponge releases fluorogestone acetate, a progestagen which is absorbed and subjects the ewe to a progestational action comparable to the luteal phase of the sexual cycle. This artificially imposed progestational phase is ended by the removal of the sponge. Injection with Folligon® (Chrono-gest PMSG) at the time of sponge removal induces a simultaneous start of the follicular phase in the treated animals. Follicles then develop and synchronised oestrus and ovulation follow.

Indications:
To induce synchronised oestrus and ovulation in Sheep.

Contra-indications:

• Do not use Chrono-gest in sheep with a vaginal discharge or in animals which have just aborted.
• Do not use Chrono-gest within 60 to 75 days after lambing.

Warnings:
Sponges eaten by animals can cause impaction. Burn the sponges after use.

Withdrawal Period:

• Milk: Nil after the insertion of the sponge.
• Meat: During the treatment and until 5 days after the removal of the sponges.

Dosage and Directions for Use:

• A single sponge is inserted into the vagina by means of the applicator supplied.
• The sponge is left in situ for 14 days.
• It is preferable to withdraw the sponges in the morning, so that mating or AI can take place during daytime. On removal of the sponge an injection of Folligon (Chrono-gest PMSG) 400-600 i.u. is given intramuscularly. During the breeding season 1 ram for 10 ewes should be provided. Hand mating i.e. presenting ewes one by one to the ram, has been shown to give the best results. A ram should be given 10 minutes rest between services.

Side-effects and Special Precautions:
None.

Known symptoms of overdosage and particulars of its treatment:
None.

Identification:
Dark grey flat round sponge with string attached to each sponge.

Storage Instructions:

• Store below 25 °C.
• Protect from light.
• Keep out of reach of children and uninformed persons.

Presentation:
25 sponges in a sealed plastic bag.

Registration holder: 
Intervet S.A. (Pty) Ltd
Co. Reg. No. 1991/006580/07